Phthalocyanine, bereits seit 75 Jahren als blaue und dann als grüne Pigmente produziert, gehören zu den wichtigsten organischen Farbmitteln. IIs sont localisés dans différentes fractions plasma-tiques et ont chacun des propriétés différentes (effet thrombobopénique ou leucopénique).2° La fixation, in vitro, sur les plaquettes sanguines de ces complexes solubles antigéne-anticorps, est variable selon les proportions d'antigénes et d'anticorps. The two antigens employed showed different behaviour.2Soluble antigen-antibody complexes are fixed much stronger upon thrombocytes than labelled antigen mixed with plasma free of antibody. Depletion of platelets, the principal reservoir of vasoactive amines, had a similar though less pronounced effect. Die Untersuchungen führten zu folgenden Ergebnissen:1Nach Injektion des homologen Antigens zirkulieren im Blut der sensibilisierten Tiere verschieden zusammengesetzte Antigen-Antikörper-Komplexe, die in verschiedenen Plasmafraktionen anfallen und verschiedene biologische Eigenschaften aufweisen, gemessen an der Wirkung auf die Thrombocyten und Leukocyten normaler Kaninchen. ResultsDiscussionReferencesDiscussionGroup DiscussionJoin ResearchGate to find the people and research you need to help your work.The effect of prostaglandin E1 in a concentration of 0.1 gamma/ml on the aggregation and disaggregation of thrombocytes and erythrocytes in vitro was studied. (3) In various experimental conditions a significant conformity was found between the formation of pyrogenic substances inin vitro experiments and the possibility of passive transfer of systemic delayed type hypersensitivity. (5) The experimental results presented are discussed from the point of view of our previous papers and with regard to contemporary knowledge on the mechanism and significance of delayed type hypersensitivity.In serum sickness, mechanisms by which circulating immune complexes become localized in the walls of vessels and glomeruli have been studied. By means of photographic records under the fluorescence microscope of sections stained for antigen, and direct observation under the light microscope of the same field subsequently stained with hematoxylin and eosin, it could be determined that the antigen was not adsorbed to chromatin or nucleoli, but was apparently in solution in the nuclear sap.The effect of antigen-antibody reactions upon thrombocytes of the rabbit has been investigated both in vitro and in vivo.For the experiments in vivo, the animals have been sensitized with human serum and human serum albumin. Ni le plasma 1523 seul, ni d'autres plasmas de lapins témoins, additionnés de gamma globuline humaine, n'ont agglutiné les plaquettes.En conclusion, il résulte de ces observations que le complexe antigéne-anticorps joue un rôle important dans les troubles plaquettaires observés au cours des réactions antigéne-anticorps. All three persisted longest in the reticulo-endothelial system and the connective tissue, and in the doses employed egg white (10 mg.) was no longer detectable after 1 day, bovine albumin (10 mg.) after 2 days, and human γ-globulin (4 mg.) after 6 days, although in a somewhat higher dose (10 mg.) human γ-globulin persisted longer than 8 days.
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The reaction was then released by intraperitoneal injection of the antigen into the sensitized rabbits. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. Any queries (other than missing content) should be directed to the corresponding author for the article.Please check your email for instructions on resetting your password. I have read and accept the Wiley Online Library Terms and Conditions of Use

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